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Pheochromocytoma : Zellballen pattern

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The histologic appearance of pheochromocytomas can be quite variable. In a typical case, the tumor consists of polygonal or spindle cells arranged in small nests (Zellballen) surrounded by sustentacular cells (best seen with S-100 immunostain; see image 35). The nests are separated by a delicate fibrovascular stroma. The nuclei are round or oval and have prominent nucleoli.

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