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Hairy Cell Leukemia : Peripheral Blood

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The morphology of hairy cells is best appreciated in the thin areas of a well-prepared peripheral blood smear. The hairy cells are 1.5 to 2 times the size of a small lymphocyte and have an oval or a bean-shaped nucleus with dispersed chromatin and inconspicuous nucleoli. The cells have moderate amount of flocculent, pale blue cytoplasm with hairy projections. The hairy cell morphology is difficult to appreciate in aspirate smears.

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