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Splenic Marginal Zone Lymphoma

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In splenic marginal zone lymphoma, the tumor is centered around the white pulp. There is an increase in the number and size of white pulp follicles and this corresponds grossly to a homogenous micronodular appearance. The splenic hilar lymph nodes are also usually involved. This splenectomy specimen is from a 60 y/o female who presented with splenomegaly. The spleen measured 21 cm in greatest dimension and weighed 1400 g. The final diagnosis was splenic marginal zone lymphoma. The cut surface shows numerous confluent nodules measuring up to 0.4 cm in size. Image copyright : pathorama.ch.

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