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Rhabdoid Tumor

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Comments:
This highly malignant renal tumor of childhood usually presents before 3 years of age. Malignant Extrarenal Rhabdoid Tumors and Composite Extrarenal Rhabdoid Tumors admixed with other phenotypes have also been recognized. Common to all these entities is the rhabdoid phenotype consisting of a high-grade, round cell tumor with abundant cytoplasm and containing cells with cytoplasmic filamentous inclusions. Cytogenetic studies have revealed karyotypic abnormalities of 22q11-12 in many cases (Am J Surg Pathol 1999 March; 23 (3):249-56.)

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