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Rhabdoid Tumor

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Cytogenetic studies have shown karyotypic abnormalities of 22q11-12 region in most rhabdoid tumors. Inactivation of INI1 - a classic tumor suppressor gene at chromosome 22q11.2 is associated with the loss of immunohistochemical expression of INI1/hSNF5/BAF47 proteins in most renal rhabdoid tumors.

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