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Glioblastoma : Epithelioid type

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Comments:
Epithelioid subtype of glioblastoma consists of tumor cells with abundant eosinophilic cytoplasm, vesicular nuclei with prominent nucleoli, and distinct cytoplasmic borders. It resembles metastatic carcinoma or melanoma which must be ruled out. This specimen is from a 26 y/o female who presented with headaches and hearing loss of sudden onset. MRI scan showed a mass in the left temporal lobe. The tumor cells were strongly positive for GFAP, weakly positive for CAM5.2 and negative for melanoma markers. Necrosis, increased mitotic activity, and endothelial proliferation were also noted in this tumor.

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