Striving to be the most comprehensive online resource for high-quality pathology images

 

Glioblastoma : Endothelial Hyperplasia

prev  
slide 15 of 24
next
No Image
Brain_Astrocytoma_GBM1_EndothelialHyperplasia3.jpg

Close

Comments:
Besides necrosis with nuclear pseudopalisading, the presence of endothelial proliferation is another histologic hallmark of glioblastomas. The image shows glomeruloid vessels (vessels with multiple lumina) and endothelial multilayering as a result of endothelial hyperplasia. These changes are driven by Vascular Endothelial Growth Factor (VEGF) secreted by the tumor in response to hypoxia. Note the focus of necrosis on the lower left.

prev
slide 15 of 24
next