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Systemic Lupus Erythematosus : Epidemiology

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Systemic lupus erythematosus (SLE) is a complex multisystem disease with cutaneous manifestations and disorders involving renal, neurologic, hematologic, and immunologic systems. The clinical presentation is highly variable. The diagnosis relies on the presence of a combination of clinical, morphologic, and serologic abnormalities that have been defined and established by the American Rheumatology Association. SLE shows strong female predominance (F:M=9:1) and is most commonly seen between 3rd and 5th decades of life.

This photograph shows the characteristic 'butterfly rash' on the cheeks and nose in a patient with SLE.

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