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Alcoholic Steatohepatitis

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Liver_AlcoholicSteatohepatitis8_Micro&Macrovesicular.jpg

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The main pathologic features of alcoholic steatohepatitis include macrovesicular steatosis, hepatocellular damage, inflammation, and pericellular fibrosis. The hepatocellular damage manifests with hepatocyte ballooning, cytoplasmic clearing, and intracytoplasmic Mallory-Denk bodies (Mallory’s hyaline). A few hepatocytes show microvesicular steatotis as well in this image. Due to altered intestinal iron absorption in chronic alcohol abuse, Kupffer cells and hepatocytes may also show mild, non-zonal iron overload.

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