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Alcoholic Steatohepatitis

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Alcoholic steatohepatitis comprises macrovesicular steatosis (as seen here), hepatocellular damage, inflammation, and fibrosis. Alcoholic steatosis is characteristically macrovesicular: large intracellular lipid droplets result in peripheral displacement of the hepatocyte nuclei. The portal tract shown here contains an inflammatory infiltrate, composed of neutrophils and lymphocytes (CD4+ or CD8+ T-cells), as well as a ductular reaction. Unlike other forms of hepatitis, plasma cells and eosinophils are rare.

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