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Cirrhosis in Total Parenteral Nutrition

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In addition to steatosis and steatohepatitis, long-term total parenteral nutrition (TPN) may result in cholestasis, hepatocellular damage, ductular reaction, fibrosis, and cirrhosis. This case of TPN-induced cirrhosis shows a prominent ductular reaction with admixed acute and chronic inflammatory cells. The golden yellow pigment in the upper right corner represents inspissated bile.

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