Striving to be the most comprehensive online resource for high-quality pathology images

 

Metanephric Adenoma : Immunohistochemistry - PAX8

prev  
slide 28 of 60
next
No Image
Kidney_MetanephricAdenoma42_PAX8_resized(1).jpg

Close

Comments:
The immunohistochemical profile of metanephric adenomas (MA) is as follows:

  • POSITIVE: WT1 (strong, nuclear), PAX8 (strong, nuclear), CD57 (cytoplasmic/membranous)
  • NEGATIVE: CK7 (may be weak, patchy +), AMACR

  • The combination of CK7-, AMACR-, CD57+ and WT1+ is considered characteristic of metanephric adenoma. Strong diffuse positivity for CK7 and AMACR argues against the diagnosis of MA and favors papillary renal cell carcinoma in the appropriate morphologic context.

prev
slide 28 of 60
next