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Metastatic Prostate Cancer in Bladder

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Prostate adenocarcinoma may involve urinary bladder by direct extension. The image shows prostate cancer (Gleason grade 5+5=10) in the lamina propria of a bladder biopsy. The tumor cells lack pleomorphism and have soft pale eosinophilic cytoplasm in contrast to the dense, glassy pink appearance of high-grade urothelial cancer. Urothelial carcinomas are also more likely to show areas of squamous differentiation.

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