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Post-radiation Sarcoma of Bladder

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This undifferentiated sarcoma arose in the urinary bladder of a patient with remote history of radiation therapy for prostate cancer. He presented with gross hematuria and was found to have a bulky bladder mass. Imaging studies suggested a primary bladder tumor. The tumor is composed of undifferentiated epithelioid and spindle cells which showed no evidence of epithelial/urothelial differentiation on immunohistochemistry.

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