Post-radiation Sarcoma of Bladder
This undifferentiated sarcoma arose in the urinary bladder of a patient with remote history of radiation therapy for prostate cancer. He presented with gross hematuria and was found to have a bulky bladder mass. Imaging studies suggested a primary bladder tumor. The tumor is composed of undifferentiated epithelioid and spindle cells which showed no evidence of epithelial/urothelial differentiation on immunohistochemistry.