Dysgerminoma : OCT3/4
Dysgerminomas show cytoplasmic and membranous staining for vimentin, PLAP, CD117 (c-kit) and D2-40 (podoplanin). There is nuclear staining for transcription factors OCT3/4 (shown here) and SALL4; both these markers show overalapping immunoreactivity in other ovarian malignant germ cell tumors as well. With cytokeratin, there is dot-like or membrane staining. EMA is usually negative. Syncytiotrophoblastic elements, when present, show cytoplasmic immunoreactivity with hCG.