Malignant Brenner Tumor : Immunostains
The immunohistochemical profile of malignant Brenner tumors is similar to their benign counterpart. They are positive for CK7, p63, GATA3, uroplakin, thrombomodulin, EMA, CEA and S-100 protein. They are usually negative or only weakly positive for CK20 and p53. The image shows malignant Brenner tumor resembling a high-grade urothelial carcinoma.