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Botryoid Rhabdomyosarcoma : Cambium Layer

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Microscopic Features of Botryoid Rhabdomyosarcoma (RMS): The individual polypoid areas are relatively hypocellular and have abundant myxoid stroma creating a resemblance to myxoma. According to the International Classification of Rhabdomyosarcoma, the defining feature of botryoid RMS is the presence of a cambium layer. It is a subepithelial condensed layer of tumor cells that is separated from the overlying epithelium by loose myxoid stroma.

Image courtesy of: Dr. Miguel Reyes-Mugica, Chief of Pediatric Pathology, University of Pittsburgh, PA, USA; used with permission.

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