Botryoid Rhabdomyosarcoma : Gross Pathology
The image shows botryoid rhabdomyosarcoma (RMS) arising in the urinary bladder of a 3 y/o male. Despite earlier definitions, grape-like gross appearance is no longer required for the diagnosis of botryoid RMS according to the International Classification of Rhabdomyosarcoma. However, a cambium layer must be present. It is a subepithelial condensed layer of tumor cells that is separated from the overlying epithelium by loose myxoid stroma. Image courtesy of: Dr. Anshuman Sinha, Patna, India; used with permission.