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Botryoid Rhabdomyosarcoma : Gross Pathology

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The image shows botryoid rhabdomyosarcoma (RMS) arising in the urinary bladder of a 3 y/o male. Despite earlier definitions, grape-like gross appearance is no longer required for the diagnosis of botryoid RMS according to the International Classification of Rhabdomyosarcoma. However, a cambium layer must be present. It is a subepithelial condensed layer of tumor cells that is separated from the overlying epithelium by loose myxoid stroma.

Image courtesy of: Dr. Anshuman Sinha, Patna, India; used with permission.

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