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Embryonal Rhabdomyosarcoma

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Rhabdomyoblasts with Cross-striations in an Embryonal Rhabdomyosarcoma (RMS): Cross-striations are usually seen in better-differentiated embryonal RMS with a prominent spindle cell component. Most elongated cells in this image have cross-striations.

Generally, there is an admixture of small undifferentiated cells and better-differentiated rhabdomyoblasts. The rhabdomyoblasts range from delicate spindle-shaped cells to large strap, ribbon, tadpole, or racket-shaped cells with deeply eosinophilic cytoplasm. The nuclei are large, round, and vesicular with a prominent nucleolus. The cross-striations in neoplastic cells are arranged irregularly and traverse only part of the cell in contrast to those seen in entrapped normal muscle cells.

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