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Large Cell NE Carcinoma

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Large cell neuroendocrine carcinomas (LCNEC) have large cells with moderate to abundant quantity of pink cytoplasm. The nuclei have vesicular chromatin and prominent nucleoli an important point of distinction from small cell carcinoma. Mitotic activity is increased (usually > 30 mitoses/2 sq.mm).

Some cases of LCNEC show well-defined areas of squamous cell carcinoma, adenocarcinoma, spindle cell carcinoma, or giant cell carcinoma. Such cases are classified as combined LCNEC and the components clearly identified in the pathology report.

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