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Squamous Cell Carcinoma

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Well-differentiated squamous cell carcinomas show keratinzation in the form of abundant eosinophilic cytoplasm, keratin pearls, and/or intercellular bridges. Non-keratinizing or poorly-differentiated tumors require immunohistochemical demonstration of one or more of squamous markers (p40, p63, CK5, or CK5/6) and lack of TTF-1 to arrive at the correct diagnosis. Intracellular mucin may be present in scattered tumor cells.

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