Multicentric or Systemic form of Castlemanís disease is usually of plasma cell type which shows diffuse plasma cell proliferation in the interfollicular region. The image shows a small follicle in the center with eosinophilic deposits of fibrin and immune complexes. Hyaline-vascular changes are absent. Plasma cell type of Castlemanís disease is often symptomatic and is accompanied by fever, anemia, elevated erythrocyte sedimentation rate, hypergammaglobulinemia, and hypoalbuminemia. In contrast, hyaline-vascular type is often asymptomatic.