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Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)

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Comments:
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a disease of unknown etiology characterized by massive, painless enlargement of cervical lymph nodes. Note the distension of sinuses by histiocytes, lymphocytes, and plasma cells diagnostic hallmark of the disease.

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