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Large Cell Calcifying Sertoli Cell Tumor

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Microscopic Features of Large Cell Calcifying Sertoli Cell Tumor: The tumor cells are arranged in solid tubules, nests, and anastomosing cords in medium amounts of fibromyxoid stroma. Neutrophilic infiltrate may be seen. Stromal calcifications are variable and range from scattered psammoma bodies to more extensive plaque-like areas. Ossification may be present.

The tumor cells have abundant eosinophilic cytoplasm. The nuclei lack pleomorphism and are round to oval with punctate nucleoli. Mitotic activity is not increased. Intratubular tumor is seen in about half of the cases.

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