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Leydig Cell Tumor : Reinke's Crystalloids

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Leydig cell tumor is composed of uniform round or polygonal cells with abundant eosinophilic cytoplasm resembling mature Leydig cells. Reinke's crystalloids are seen in about 30-40% of cases and appear as dense needle-like or rhomboid structures in the cytoplasm. They are difficult to visualize in histologic sections but are more readily seen in touch-preps made from the freshly cut tumor surface.

This touch-prep was air-dried and stained with Diff-Quik stain. Several plump rod-shaped or rhomboid intracytoplasmic crystals of Reinke can be seen in the center of the image.

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