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Germ Cell Neoplasia in situ : PLAP

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Immunoreactivity for Placenta-like Alkaline Phosphatase (PLAP) with cytoplasmic membrane staining and some cytoplasmic staining is a quite sensitive and a specific marker for germ cell neoplasia in situ (GCNIS). Normal germ cells and Sertoli cells are negative for PLAP.

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