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Microglandular Adenosis

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Microglandular adenosis (MGA) is composed of small uniform glands irregularly distributed in fibrofatty stroma. The glands are lined by a single layer of uniform cuboidal or flattened cells with regular nuclei and punctuate nucleoli. The glandular lumens are round and contain eosinophilic secretions. The glands lack myoepithelial layer; however, a thick basement membrane is present that can be highlighted by reticulin stain. MGA is considered to be a lesion with premalignant potential and should be completely excised with negative margins. Carcinoma has been found in up to 30% of cases of MGA.

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