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Solid and Pseudopapillary Tumor of Pancreas

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The image shows microscopic areas of delicate infiltration into the surrounding non-neoplastic pancreas. Although most tumors are grossly well-demarcated from the normal pancreas, neoplastic cells can infiltrate into the surrounding pancreatic tissue, entrapping acinar cells and islets. To date, no pathologic criteria can reliably predict high risk for aggressive behavior; however, perineural invasion, angioinvasion, deep infiltration of the surrounding pancreas, significant nuclear atypia, and an unusually high mitotic rate have been proposed as features predictive of malignant behavior.

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