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Urothelial Carcinoma in Prostate

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Higher magnification of the previous image. When faced with a high-grade carcinoma in a prostate needle biopsy, the features favoring urothelial carcinoma include: tumor growing in nests; marked nuclear pleomorphism with giant tumor nuclei; dense eosinophilic cytoplasm; squamous differentiation; necrosis; positivity for p63 and HMWCK; negativity for prostatic markers.

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