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Hepatocellular Carcinoma in Hemochromatosis

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The HCC (left) shows a prominent acinar (pseudoglandular) pattern and is well-demarcated from the native liver parenchyma, which shows marked hemosiderin deposition. Long-standing hemochromatosis often results in significant hemosiderin deposition in hepatocytes and increased risk of hepatocarcinogensis. Hemosiderin can be distinguished from bile by positive iron stains.

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