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Fatty Liver of Pregnancy

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The image shows microvesicular steatosis, hypertrophied Kupffer cells with lipofuscin pigment, and mononuclear infiltrate in the lobules in a case of acute fatty liver of pregnancy. Since the pathogenesis involves a fetal metabolic deficiency causing long-chain fatty acid overload in maternal circulation putting strain on the liver, the mainstay for therapy is early delivery/termination of the pregnancy and supportive care.

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