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Prostate Cancer : Neuroendocrine Cells

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When evaluated with immunohistochemical markers, neuroendocrine differentiation is seen in a high proportion of prostatic adenocarcinomas (between 30% to 100%). In about 10% of cases, it can be recognized on routine H&E stains due to the presence of large eosinophilic granules in the cytoplasm. The image shows a cluster of such cells in Gleason score 4+4=8 adenocarcinoma.

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