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Crohn Disease : Microscopic

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Non-caseating epithelioid granulomas are one of the diagnostic hallmarks of Crohn disease. They are found in 40-60% of cases; therefore, absence of granulomas does not exclude Crohn disease. They may be present in any layer of the intestine, inflamed or non-inflamed regions, and even in mesenteric lymph nodes.

This is a colectomy specimen from Crohn Disease. An epithelioid granuloma can be seen in the center of the image. Image courtesy of Dr. Jean-Christophe Fournet, Paris, France; humpath.com; Used with permission.

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