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Crohn Disease : Microscopic

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Microscopic Features of Crohn Disease: There is considerable overlap in histologic features between Crohn disease and ulcerative colitis. Deep ulcers and fissures, transmural inflammation, and epithelioid granulomas are diagnostic hallmarks of Crohn disease.

This is a colectomy specimen from a patient with Crohn disease. A small focus of uninvolved mucosa in the center is surrounded by ulcers on either side. There is transmural inflammation and numerous lymphoid aggregates and granulomas.

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