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Malignant GIST

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Comments:
This malignant GIST demonstrates nuclear pleomorphism and hyperchromasia, and >5 mitotic figures/50 HPFs. Malignant GISTs still typically harbor CKIT mutations. These lesions often respond to treatment with imatinib (Gleevec), which is given to patients with malignant GISTs after surgical resection.

slide 25 of 30