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Post-atrophic Hyperplasia : HMWCK + p63

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Prostate_BMCaP_PAH5.jpg

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The distinction of post-atrophic hyperplasia from adenocarcinoma usually does not pose a diagnostic challenge. In rare cases with somewhat overlapping features, immunostaining with basal cell-specific markers can help. The image shows strong staining with high molecular weight cytokeratin and p63 in a focus of post-atrophic hyperplasia. Note the lobular arrangement of the glands.

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