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Prostatic xanthoma: CD68 immunostain

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Comments:
In diagnostically challenging cases, a panel of immunostains consisting of CD68, CAM5.2, PSA and PSAP may be helpful in distinguishing prostatic xanthomas from high-grade prostatic adenocarcinoma. Most prostatic xanthomas are diffusely positive for CD68 (shown here), and negative for CAM5.2, PSA, and PSAP. Rare cases may be positive for prostatic markers. Chuang A, Epstein JI. Xanthoma of the Prostate. Am J Surg Pathol 2007; 31:1225-1230.

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