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High-grade PIN : Flat type

slide 23 of 32

Comments:
In the initial stages of proliferative changes of high-grade PIN, epithelial hyperplasia is minimal. The atypical cells form two to three layers of cells arranged in an orderly fashion around the gland. This is the flat subtype of high-grade PIN as shown here. Note the nuclear enlargement and hyperchromasia, prominent nucleoli, and partial involvement of the gland.

slide 23 of 32