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Barrett Esophagus : High-grade Dysplasia

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Dysplasia in Barrett esophagus is dividied into low-grade and high-grade. The image shows high-grade dysplasia. The glands are crowded and irregularly shaped and there is nuclear hyperchromasia, increased mitotic activity, and prominent nucleoli. Dysplastic changes are most often seen in the areas of incomplete intestinal metaplasia.

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