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Oral Squamous Papilloma : Differential

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Clinically, squamous papilloma of the oral cavity can resemble verruca vulgaris, condyloma acuminatum, verruciform xanthoma, or multifocal epithelial hyperplasia. Several syndromes and skin disorders are associated with papillomatosis of the oral cavity, including nevus unius lateralis, acanthosis nigricans, focal dermal hypoplasia (Goltz syndrome), and Down syndrome.

The image shows a few papillary projections lined by keratinizing stratified squamous epithelium around fibrovascular cores.

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