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Salivary Duct Carcinoma

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Histologically, salivary duct carcinomas resemble ductal carcinoma of the breast. This image shows solid nests with central comedonecrosis.

Morphologic features frequently noted in the invasive areas include absence of myoepithelial layer, large cystic foci, stromal fibrosis, absence of normal salivary parenchyma within neoplastic foci, angioinvasion, perineural invasion, and invasion of surrounding soft tissues.

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