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Mammary Analogue Secretory Carcinoma

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Mammary analogue secretory carcinoma (MASC) is a relatively recently described low-grade salivary gland neoplasm which is identical to its mammary counterpart at morphologic as well as molecular genetic levels. The majority of cases involve the parotid gland and a small proportion occur in the minor salivary glands.

MASC usually consists of multiple lobules separated by fibrotic stroma. The lobules display a variety of architectural patterns, including solid, microcystic, macrocystic, papillary, tubular and cribriform.

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