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Extranodal Rosai-Dorfman Disease : Skin

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Cutaneous Rosai-Dorfman disease (CRDD) makes up about 9% of cases of RDD. It is clinically distinct from RDD and it may be a different but related condition. The patients are older (usually in their 4th decade) as compared to RDD and there is a female predilection. CRDD is more common in Caucasians and Asians. The disease is limited to skin and there is usually no adenopathy or systemic involvement.

The image shows dense infiltrate of lymphocytes and histiocytes in the dermis and subcutis in a case of CRDD.

Image courtesy of: Vishwas Parekh, MD; used with permission.

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