Facebook Icon Twitter icon Instagram icon Feedback

Mixed Cellularity Hodgkin Lymphoma

prev slide 58 of 83 next
No Image


Mixed cellularity classic Hodgkin lymphoma (cHL) is the second most common subtype and accounts for about 25% of all cHLs. It is more frequent in patients with HIV infection and in resource-poor areas. The patients tend to be older and present at more advanced stages, usually stage III or IV and with B symptoms.

Lymph node groups below or on both sides of diaphragm are involved. Splenic and bone marrow involvement is seen in 30% and 10% of cases respectively. Mediastinal lymph nodes are usually spared. The affected lymph node is enlarged with diffuse effacement of the nodal architecture.

About this Image: This specimen of mixed cellularity cHL is from an adult female who presented with inguinal lymphadenopathy. The lymph node is considerably enlarged with a fleshy homogenous cut surface. Note the lack of nodularity and fibrous bands, unlike in nodular sclerosis cHL.

prev slide 58 of 83 next