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Mixed Cellularity Hodgkin Lymphoma

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Mixed cellularity classic Hodgkin lymphoma (cHL) is the second most common subtype and accounts for about 25% of all cHLs. It is more frequent in patients with HIV infection and in resource-poor areas. The patients tend to be older and present at more advanced stages, usually stage III or IV and with B symptoms.

Lymph node groups below or on both sides of diaphragm are involved. Splenic and bone marrow involvement is seen in 30% and 10% of cases respectively. Mediastinal lymph nodes are usually spared. The affected lymph node is enlarged with diffuse effacement of the nodal architecture.

About this Image: This specimen of mixed cellularity cHL is from an adult female who presented with inguinal lymphadenopathy. The lymph node is considerably enlarged with a fleshy homogenous cut surface. Note the lack of nodularity and fibrous bands, unlike in nodular sclerosis cHL.

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