Genitourinary Tract

Genitourinary Tract

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Friday, September 10, 2010               
 
 Mixed Germ Cell Tumor
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1: Mixed Germ Cell Tumor : Gross
Comments: Mixed germ cell tumors have a variegated gross appearance due to admixture of different germ cell tumor elements. This tumor was composed of embryonal carcinoma and mature teratoma. The pearly white areas seen grossly corresponded to hyaline cartilage.
2: Mixed Germ Cell Tumor : Gross
Comments: This mixed germ cell tumor was composed of seminoma (salmon-colored areas on either side of the bivalved specimen) and immature teratoma consisting of primitive neuroepithelium and blastema (soft pink-white area in the center of the image resembling brain tissue).
3: Mixed Germ Cell Tumor : Teratoma
Comments: This mixed germ cell tumor had areas of mature teratoma and embryonal carcinoma. The photomicrograph shows hyaline cartilage. Intestinal type glands were also present nearby.
4: Mixed Germ Cell Tumor : Embryonal Carcinoma
Comments: Mixed germ cell tumor (same case as previous illustration) showing embryonal carcinoma component. The tumor had abundant primitive stroma.
5: Mixed Germ Cell Tumor
Comments: This is a left orchiectomy specimen from a 30 year old male who presented with a 6 month history of painless enlargement of left testicle. Testicular ultrasound revealed a solid mass with increased vascularity suspicious for a neoplasm. It was a mixed germ cell tumor consisting of embryonal carcinoma and yolk sac tumor components.
6: Mixed Germ Cell Tumor : Polyembryoma pattern
Comments: Polyembryoma is a distinct pattern of mixed germ cell tumor that attempts to recapitulate embryonic architecture. In this image, three embryoid bodies are seen. Each is composed of a central portion of embryonal carcinoma between a ventral yolk sac tumor component and a dorsal amnion-like space.
7: Mixed Germ Cell Tumor : Polyembryoma pattern
Comments: This photomicrograph shows embryoid body surrounded by myxoid vascular stroma. Alpha fetoprotein is often elevated in these cases due to the yolk sac component.
Last Updated: Tuesday, August 03, 2010
 
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