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1:
Choriocarcinoma
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Comments: Choriocarcinoma is an uncommon testicular germ cell tumor that is usually seen as a component of mixed germ cell tumor. Many patients present with metastases to lung or brain. This image shows admixture of polygonal cells with clear cytoplasm (cytotrophoblast) and large multinucleated cells with smudged nuclear chromatin (syncytiotrophoblast).
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2:
Choriocarcinoma
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Comments: Cytotrophoblastic cells may be arranged in sheets or villous-like architecture in a hemorrhagic background.
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3:
Choriocarcinoma
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Comments: A “cap” of syncytiotrophoblastic cells is seen in this hemorrhagic and necrotic focus of choriocarcinoma. In some cases, the necrotic and hemorrhagic areas regress and a residual scar is the only evidence of prior existence of the tumor.
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4:
Choriocarcinoma
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Comments: This image shows abundant syncytiotrophoblasts. In some cases, they may be inconscpicuous or even absent.
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5:
Choriocarcinoma
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Comments: In classic cases of choriocarcinoma, syncytiotrophoblasts form a “cap” around clusters of cytotrophoblasts in an attempt to mimic the architecture of immature placental villi.
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