Breast

Breast

   Home | About this Site | Feedback | Site Map
Monday, September 06, 2010               
 
 Ductal Carcinoma-in-situ
  Back to Breast Carcinomas | Return to Breast
1: Ductal Carcinoma-in-situ : Micropapillary
Comments: The micropapillary variant of DCIS showing slender elongated epithelial fronds projecting into the glandular lumen. These projections are solid and lack true fibrovascular cores. They are composed of a uniform population of tumor cells with intermediate nuclear grade.
2: Ductal Carcinoma-in-situ : Micropapillary
Comments: The papillae in this case of micropapillary DCIS range from small bumps or mounds of tumor cells to slender papillary structures. The nuclear grade is high. Some of the papillary fronds projecting into the lumen may be cut transversely resulting in appearance of small detached irregular clusters of tumor cells in the lumen (as seen here). Cellular debris, usually a feature of cases with high nuclear grade, is also present in the lumen.
3: Ductal Carcinoma-in-situ : Micropapillary
Comments: The papillary structures in this example of micropapillary DCIS show bulbous expansion of their tips. Some of the adjacent papillary fronds have coalesced creating Roman bridge arches. When fusion between adjacent fronds is extensive, it results in formation of cribriform structures. Micropapillary and cribriform patterns of DCIS often coexist.
4: Ductal Carcinoma-in-situ : Cribriform
Comments: In the cribriform DCIS, round fenestrations are found within the glands. The more regular these spaces are in size, shape and distribution, the more likely the lesion to be malignant. Cribriform DCIS shows superficial resemblance to adenoid cystic carcinoma and collagenous spherulosis and should not be mistaken for those entities.
5: Ductal Carcinoma-in-situ : Cribriform with Microcalcifications
Comments: High power view of cribriform DCIS showing microcalcifications.
6: Ductal Carcinoma-in-situ : Cribriform
Comments: A case of cribriform DCIS showing fenestrations, Roman bridges, and trabecular bars.
7: Ductal Carcinoma-in-situ
Comments: The tumor cells with high nuclear grade nearly fill the lumen in this example of DCIS. The cytoplasmic borders are sharply demarcated.
8: Ductal Carcinoma-in-situ
Comments: Carcinoma cells are present within structures clearly identifiable as a lobule. The lobule is greatly expanded by its involvement with DCIS. The tumor cells have high nuclear grade. The phenomenon of lobular cancerization further supports the notion of terminal duct-lobular unit as the site of origin of many of the intraductal carcinomas.
9: Ductal Carcinoma-in-situ : Apocrine
Comments: This case of DCIS shows apocrine-type cytology with carcinoma cells having abundant granular eosinophilic cytoplasm and pleomorphic nuclei. The architectural pattern is clinging type.
10: Ductal Carcinoma-in-situ : Comedonecrosis
Comments: In DCIS with comedonecrosis, the involved duct shows a solid growth with high nuclear grade along the perimeter of the duct. Mitotic activity is brisk and necrosis is always present in the lumen. Coarse calcifications may be present in the necrosis. The periductal tissue shows fibrosis and evidence of angiogenesis.
Last Updated: Tuesday, August 03, 2010
 
SLIDE INDEX
Brain
Head & Neck
Mediastinum
Lungs Pleura
Lymph Nodes Spleen
Heart Blood Vessels
Gastrointestinal Tract
Female Genital Tract
Genitourinary Tract
Bone & Cartilage
Soft Tissue
Peritoneum
Endocrine
Breast
Benign Prolif. Lesions
Breast Carcinomas
Rare Breast Tumors
Inflammatory/Reactive
Skin
 
SEARCH  
twitter