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Hamartomatous Polyps

Reviewers: Dharam M. Ramnani, MD


Hamartomatous polyps of gastrointestinal tract occur sporadically as well as components of genetic or acquired syndromes. When occurring in the syndromic setting, some of them are associated with germline mutations in tumor suppressor genes or oncogenes and carry increased risk of malignancies. Juvenile polyps and polyps associated with Peutz-Jeghers Syndrome will be addressed in this section.

References:
1. Feldman, M., Friedman, L. S., & Brandt, L. J. (2016). Sleisenger & Fordtran’s Gastrointestinal & Liver Disease – 10th Edition. Philadelphia, PA. Elsevier Saunders.
2. Goldblum, J. R. et al (2018). Rosai and Ackerman’s Surgical Pathology – Eleventh Edition. Philadelphia, PA. Elsevier.
3. Kumar, V., Abbas, A. K., & Aster, J. C. (2015). Robbins and Cotran Pathologic Basis of Disease – Ninth Edition. Philadelphia, PA. Elsevier.

Juvenile (Retention) Polyp

Peutz-Jeghers Polyp