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1:
Atypical Small Acinar Proliferation in Prostate
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Comments: A serum PSA of 4.5 ng/ml resulted in this needle biopsy. Digital rectal examination and prostate ultrasound were normal. A single atypical focus (shown here) was found among 10 cores. The features are highly suspicious for adenocarcinoma, but were felt to be insufficient for an unequivocal diagnosis.
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2:
Atypical Small Acinar Proliferation in Prostate
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Comments: Another example of atypical small acinar proliferation suspicious for but not diagnostic of malignancy. This case was reviewed by an expert who concurred with the atypical diagnosis. For some observers, this focus may be diagnostic of adenocarcinoma.
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4:
Adenocarcinoma in Repeat Biopsy
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Comments: A repeat biopsy performed three months later (same case as previous image) showed an unequivocal focus of adenocarcinoma (Gleason 3+3=6). Interestingly, the cancer was in a location different from the atypical focus in the previous biopsy
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